2-MSP-5-HA-GGFG-NH-CH2-O-CH2-CO-Exatecan

SKU: orb2564829

Description

This research compound is a cleavable drug-linker conjugate designed for constructing Antibody-Drug Conjugates (ADCs), specifically for coupling the potent topoisomerase I inhibitor Exatecan to an anti-HER3 antibody. It is utilized in preclinical in vitro and in vivo studies to investigate targeted cancer therapies, particularly against HER3-expressing tumors.

Research Area

Molecular Biology

Images & Validation

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Key Properties

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CAS Number	2964536-59-0
MW	1091.13
Formula	C₅₃H₅₅FN₁₀O₁₃S
SMILES	N(C(COCNC(CNC([C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCC#CC=2C=NC(S(C)(=O)=O)=NC2)=O)=O)=O)=O)=O)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8
Target	Drug-Linker Conjugates for ADC,Topoisomerase

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

171038185 ↗

Key Properties

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No computed properties available.

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