BRL 52537 hydrochloride is a selective and specific KOR agonist which has been implicated in neuroprotection from ischemic neuronal injury. It is used for research into potential treatments for stroke and heart attack as well as more general brain research.(In Vivo):In rats treated with BRL 52537 during ischemia and early reperfusion, infarct volume was significantly attenuated in cortex and in caudoputamen.