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CD1a Antibody

SKU: orb640020

Description

At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).

Images & Validation

Tested ApplicationsELISA
Dilution rangeELISA (order BSA-free format for coating)
ReactivityHuman
Application Notes
Optimal dilution of the antibody should be determined by the researcher.

Key Properties

Antibody TypePrimary Antibody
HostMouse
ClonalityMonoclonal
IsotypeMouse IgG2b, kappa
Clone No.C1A/3249
ImmunogenA recombinant human partial protein (amino acids 43-173) was used as the immunogen for this CD1a antibody.
ConjugationUnconjugated

Storage & Handling

StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
DisclaimerFor research use only

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CD1a Antibody

Analysis of HuProt (TM) microarray containing more than 19000 full-length human proteins using CD1a antibody (clone C1A/3249). These results demonstrate the foremost specificity of the C1A/3249 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

CD1a Antibody

SDS-PAGE analysis of purified, BSA-free CD1a antibody (clone C1A/3249) as confirmation of integrity and purity.

UniProt Details

No UniProt data available

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Protocol Information

ELISA
Enzyme-linked Immunosorbent Assay (EIA)
View Protocol

CD1a Antibody (orb640020)

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Available Sizes

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20 μg
$ 410.00
100 μg
$ 780.00
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