CHIKV nsP2 protease-IN-1 (J13) is a potent, orally bioavailable inhibitor of the Chikungunya virus nsP2 protease, demonstrating antiviral activity with an EC50 of 0.39 μM against the CH S27 strain. It serves as a valuable research tool for studying CHIKV replication and pathogenesis in both cellular and animal models.