Hycanthone

SKU: orb1308221

Description

Hycanthone mesylate is a potent antischistosomal agent that functions as a DNA intercalator, inhibiting RNA synthesis and topoisomerases I/II. It also directly binds and inhibits APE1 (KD: 10 nM), disrupting nucleic acid biosynthesis. This compound has been utilized in molecular parasitology research, including studies on schistosome infection models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	3105-97-3
MW	356.48
Purity	98.78% (May vary between batches)
Formula	C₂₀H₂₄N₂O₂S
SMILES	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12
Target	DNA/RNA Synthesis,Topoisomerase,Parasite
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.81 mM);H2O:< 0.1 mg/mL (insoluble);DMSO:18 mg/mL (50.49 mM)

Bioactivity

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Target IC50	APE1:10 nM(Kd)
In Vivo	Male worms treated with Hycanthone display signs of possible partial recovery from the initial low levels of incorporation. After treatment with Hycanthone, the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease. Immature worms are totally unaffected by Hycanthone at all times tested. In the first four days after treatment, incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50%. 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules . Read more...
In Vitro	Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Compared to that of controls, results show that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively decreases viral interferon yields as much as 73% . Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Parasite, nucleic, Lucanthone, inhibit, Hycanthone, Etrenol(mesylate), endonuclease-1, Inhibitor, intercalator, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, acid, anti-schistosomal, apurinic, APE1, biosynthesis, RNA Synthesis, RNASynthesis, Win 249-33, thioxanthenone, Topoisomerase II, Topoisomerase I, Topoisomerase

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Compound Identifiers

PubChem CID

3634 ↗

Key Properties

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No computed properties available.

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Hycanthone (orb1308221)

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Purity:	>98% (HPLC)
CAS Number:	3105-97-3
MW:	356.48
Formula:	C₂₀H₂₄N₂O₂S

Hycanthone

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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