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Lipid N2-3L

SKU: orb2815803

Description

Lipid N2-3L is an ionizable cationic lipid with a pKa of 8.99, utilized in the formation of supramolecular lipid nanoparticles (SMLNPs) for enclosing mRNA in both in vitro and in vivo applications. Lipid N2-3L-containing SMLNPs accumulate at the injection site and draining lymph nodes in mice, featuring a luciferase reporter gene. Additionally, SMLNPs made with Lipid N2-3L that encapsulate ovalbumin mRNA and the Toll-like receptor 7/8 (TLR7/8) agonist R-848 serve as adjuvants. These enhance dendritic cell maturation and antigen presentation, reducing tumor volume and increasing survival rates in MC-38-OVA colon cancer mouse models.

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Key Properties

CAS Number2924606-55-1
MW840.27
FormulaC48H93N3O8
SMILESC(C(OCCN(CCOC(NCCCN(CCO)CCO)=O)CCOC(CCCCCCC/C=C\CCCCCCCC)=O)=O)(CCCCCCCC)CCCCCC

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Lipid N2-3L (orb2815803)

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