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PNU-120596

SKU: orb1222158

Description

PNU-120596, also known as NSC 216666, is α7 nicotinic acetylcholine receptor positive allosteric modulator. PNU-120596 reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats. PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates.

Images & Validation

Key Properties

CAS Number501925-31-1
MW311.72
Purity>98% (HPLC)
FormulaC13H14ClN3O4
SMILESCOc1cc(OC)c(NC(=O)Nc2noc(C)c2)cc1Cl
TargetThrombin
SolubilityDMSO : 50 mg/mL 160.40 mM;

Bioactivity

In Vivo
Animal model: Male Sprague Dawley rats (250-300 g) treated with Amphetamine. Dosage: 1 mg/kg. Administration: Intravenous injection; once. Result: Improved the auditory gating deficit caused by Amphetamine.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PNU-120596 | PNU 120596 | PNU120596 | NSC 216666

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  • PNU-120596 [orb1300318]

    98.34%

    501925-31-1

    311.72

    C13H14ClN3O4

    1 ml x 10 mM (in DMSO), 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg
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PNU-120596 (orb1222158)

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Available Sizes

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500 mg
5 mg
$ 80.00
10 mg
$ 110.00
25 mg
$ 180.00
50 mg
$ 310.00
100 mg
$ 530.00
200 mg
$ 760.00