Tin-protoporphyrin IX dichloride

SKU: orb1708354

Description

Tin-protoporphyrin IX dichloride (SnPPIX) is a potent heme oxygenase-1 (HO-1) inhibitor. It has demonstrated antiviral activity against flaviviruses, including dengue and yellow fever, in both in vitro cell culture studies and in vivo animal models of infection.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	14325-05-4
MW	750.26
Purity	98.00% (May vary between batches)
Formula	C₃₄H₃₂Cl₂N₄O₄Sn
SMILES	O=C(CCC1=C(C)C2=CC3=C(C)C(C=C)=C4C=C5C(C)=C(C=C)C6=[N]5[Sn+4]([Cl-])([Cl-])([N-]43)([N-]78)[N]2=C1C=C8C(CCC([O-])=O)=C(C)C7=C6)[O-].[H+].[H+]
Target	Virus Protease,Reactive Oxygen Species,ROS,Autophagy
Solubility	0.1M NaOH:10 mg/mL (13.33 mM);DMSO:5 mg/mL (6.66 mM)

Bioactivity

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Target IC50	HO-1:
In Vivo	In male and female athymic nude mice with PDAC cell-derived xenograft tumors, Tin protoporphyrin IX dichloride (5 mg/kg; Intraperitoneal injection; on days 1, 4, 6, 8, 11, 13, 15, 18, and 20) inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine). Read more...
In Vitro	In Capan-1, CD18/HPAF, and PDAC cells, Tin protoporphyrin IX dichloride (20 μM, 50 μM; 24 or 72 hours) inhibited proliferation of Capan-1 and CD18/HPAF cells and inhibited growth of PDAC cells at 50 μM. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Dengue Fever virus, (HO)-1, Heme oxygenase-1, SnPPIX, SnPPIX dichloride, Tin protoporphyrin IX, Tin-protoporphyrin IX, Tinprotoporphyrin IX, Virus Protease, VirusProtease

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Gene Symbol

Virus Protease,Reactive Oxygen Species,ROS,Autophagy

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