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Featured
Description
Research Area
Cell Biology, Cytotoxic Cells, Immue System, Immunology, Stem Cell Research
Images & Validation
−Item 1 of 3
| Tested Applications | FC, IF, IHC-Fr, IHC-P, WB |
|---|---|
| Dilution Range | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=2ug/Test |
| Reactivity | Human |
| Predicted Reactivity | Bovine, Mouse, Porcine, Rat |
Related Conjugates & Formulations
−Key Properties
−| Antibody Type | Primary Antibody |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | KLH conjugated synthetic peptide derived from human GZMB (21-130/247aa) |
| Target | GZMB |
| Molecular Weight | 35 kDa |
| Purification | Affinity purified by Protein A |
| Conjugation | Unconjugated |
Storage & Handling
−| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
|---|---|
| Form/Appearance | Liquid |
| Buffer/Preservatives | 0.01M TBS (pH7.4) with 1% rAlbumin, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Expiration Date | 12 months from date of receipt. |
| Disclaimer | For research use only |
Alternative Names
−C11; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA1; CTSGL1; HLP; SECT; CCP-1/C11; CCP1; Ctla-1; GZB; RNKP-1; GRAB_HUMAN; GZMB; Cathepsin G-like 1 (CTSGL1); Cytotoxic T-lymphocyte proteinase 2 (Lymphocyte protease); Fragmentin-2; Granzyme-2; Human lymphocyte protein (HLP); T-cell serine protease 1-3E; 3.4.21.79; GRB; GRAB_MOUSE; Cytotoxic cell protease 1 (CCP1); GRAB_RAT; Fragmentin; Natural killer cell protease 1; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); cytotoxic serine protease B; cathepsin G-like 1; granzyme 2; cytotoxic T-lymphocyte-associated serine esterase 1
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Quick Database Links
Gene Symbol
GZMB
UniProt
UniProt Details
− No UniProt data available
Protocol Information
WB
Western Blot (IB, immunoblot)
IHC-P
Immunohistochemistry Paraffin
IHC-Fr
Immunohistochemistry Frozen
FC
Flow Cytometry
IF
Immunofluorescence
Reeves, Kirsten M. et al. 18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition Clin Cancer Res, 28, 327-337 (2022)













