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MYCi975

SKU: orb1709073

Description

MYCi975

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number2289691-01-4
MW561.3
Purity99.30%
FormulaC25H16Cl2F6N2O2
SMILESO(CC1=CC=C(Cl)C=C1)C2=C(C(O)=C(C=C2)C3=CC(C(F)(F)F)=NN3C)C4=CC(C(F)(F)F)=C(Cl)C=C4
Targetc-Myc
SolubilityDMSO:247.5 mg/mL (440.94 mM)

Bioactivity

In Vivo
The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. however, 361 demonstrated a narrow therapeutic index. An improved analog, MYCi975 showed better tolerability.
In Vitro
MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner IC50 of 3.7, 3.9, 6.4 μM, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

cMyc, c-Myc, MYC, MYCi975, MYCi-975, NUCC 0200975, NUCC0200975, NUCC-0200975

Similar Products

  • MYCi975 [orb1219642]

    >98% (HPLC)

    2289691-01-4

    561.3

    C25H16Cl2F6N2O2

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 g, 500 mg
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Key Properties

No computed properties available.

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MYCi975 (orb1709073)

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Available Sizes

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1 mg
$ 170.00
5 mg
$ 340.00
1 ml x 10 mM (in DMSO)
$ 430.00
10 mg
$ 540.00
25 mg
$ 860.00
50 mg
$ 1,170.00
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