SM-102

SKU: orb1298110

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Description

SM-102 is a clinically approved ionizable cationic lipid used to formulate lipid nanoparticles (LNPs) for mRNA delivery. It is a key component in research for developing mRNA vaccines and therapeutics, with applications in both in vitro and in vivo studies.

Research Area

Metabolism Research

Images & Validation

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Item 1 of 1

Key Properties

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CAS Number	2089251-47-6
MW	710.17
Purity	99.75% (May vary between batches)
Formula	C₄₄H₈₇NO₅
SMILES	CCCCCCCCCCCOC(=O)CCCCCN(CCO)CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC
Target	Liposome,Others
Solubility	DMSO: 55 mg/mL (77.45 mM), Sonication is recommended. Ethanol: 100 mg/mL (140.81 mM), Sonication is recommended.

Bioactivity

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Target IC50

IK (erg):108 μM|IK (erg) (MA-10 cells):98 μM

In Vitro

METHODS: The effects of SM-102 on ionic currents in two endocrine cells, rat pituitary tumor (GH3) cells and mouse Leydig tumor (MA-10) cells, or microglial cells (BV2), were investigated. Hyperpolarization-activated K currents in these cells bathed in a high-K, Ca2+-free extracellular solution were examined to assess the effects of SM-102 on the amplitude and hysteresis of erg-mediated K currents (I+K(erg)). RESULTS The addition of SM-102 effectively blocked IK(erg) in a concentration-dependent manner with a half-peak concentration (IC50) of 108 μM, which was similar to the KD value required for its enhanced current inactivation time constant (i.e., 134 μM); in the presence of SM-102, exposure of cells to the transfection reagent TurboFectinTM 8.0 (0.1%, v/v) was able to effectively inhibit hyperpolarization-activated IK(erg) and increase the inactivation time course of the current; in addition, in GH3 cells dialyzed with spermine (30 μM), the amplitude of IK(erg) gradually decreased; further use of SM-102 (100 μM) or TurboFectin (0.1%) further reduced the current amplitude; in MA-10 Leydig cells, the IC50 value of SM-102-induced IK(erg) inhibition in MA-10 cells was 98 μM. In BV2 microglia, the amplitude of inwardly rectifying K currents is inhibited by SM-102.

Storage & Handling

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Storage	Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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SM102, SM-102, SM 102, vaccines, COVID-19, delivery, mRNA, lipid nanoparticle, inhibit, Inhibitor

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Chemical Structure of orb1298110

Compound Identifiers

PubChem CID

126697616 ↗

Key Properties

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No computed properties available.

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SM-102 (orb1298110)

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Purity:	>98%
CAS Number:	2089251-55-6
MW:	822.4
Formula:	C₅₂H₁₀₃NO₅

Purity:	0.95
MW:	594.528
Formula:	C₃₆H₇₁NO₃Si

Purity:	0.98
MW:	663.1
Formula:	C₄₁H₇₉N₃O₃

Purity:	0.98
MW:	828.34
Formula:	C₅₃H₉₂F₃N₃

Purity:	0.98
MW:	1021.78
Formula:	C₆₄H₁₃₂N₄O₄

SM-102

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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SM-102 (orb1298110)

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