TBR1 Rabbit Polyclonal Antibody (BF680)

SKU: orb2542730

Description

Images & Validation

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Tested Applications	ICC, IF
Dilution range	ICC/IF=1:50-200, IF=1:100-500
Predicted Reactivity	Bovine, Canine, Equine, Gallus, Human, Mouse, Porcine, Rat, Sheep

Related Conjugates & Formulations

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Key Properties

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Antibody Type	Primary Antibody
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Immunogen	KLH conjugated synthetic peptide derived from human TBR1 (35-130/682aa)
Target	TBR1
Purification	Affinity purified by Protein A
Conjugation	BF680

Storage & Handling

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Storage	Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Buffer/Preservatives	0.01M TBS (pH7.4) with 1% rAlbumin, 0.02% Proclin300 and 50% Glycerol.
Concentration	1mg/ml
Disclaimer	For research use only

Alternative Names

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A novel murine and human gene, TBR-1, encodes a putative transcription factor related to the Brachyrury(T) gene that is expressed only in postmitotic cells. T-brain-1(TBR-1) mRNA is largely restricted to the cerebral cortex, where, during embryogenesis, it defines different regions that give rise to the palecortex, limbic cortex and neocortex(1-3). TBR-1, Pax-6 and Emx-1 are expressed in the mouse and chicken pallium. The pallio-subpallial boundary lies at the interface between the TBR-1 and Dlx-2 expression domains. Chicken genes homolgous to these mouse genes are expressed in topologically comparable patterns during development, suggesting that mouse and chicken may have similar histogenetic specification processes and field homologies(4). CASK/LIN-2, a membrane-associated guanylate kinase, is required for EGFR localization and signaling. In adult rat brain, CASK is concentrated at neuronal synapses and binds to the cell-surface proteins. CASK can interact with TBR-1, which is involved in forebrain development. CASK enters into the nucleus and binds to a specific DNA sequence(the T-element) in a complex with TBR-1. Thus, CASK acts as a coactivator of TBR-1 to induce transcription of T-element containing genes, including reelin(5); TBR1_HUMAN.

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Gene Symbol

TBR1

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Protocol Information

Immunofluorescence

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ICC

Immunocytochemistry

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