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123B9

SKU: orb2645894

Description

123B9 is a tumor-homing agent characterized as a potent and selective agonist for EphA2 with a dissociation constant (Kd) of 4.0 μM. It specifically targets the ligand-binding domain of the EphA2 tyrosine kinase receptor. Notably, 123B9 does not significantly inhibit the ligand-binding domains of closely related receptors EphA3 and EphA4.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number2225868-19-7
MW1321.79
FormulaC58H82ClFN12O20
SMILESC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC(COC2=CC(Cl)=C(F)C=C2)=O)CO)=O)C)=O)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CO)=O)CCO)=O)CCCC)=O)CCC4)[C@@H](C)C)=O)CO)=O)CC(O)=O)=O)CCC3
TargetEphrin Receptor

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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123B9 (orb2645894)

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