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Nanobodies, or single-domain antibodies (VHH) derived from camelid species (Alpaca/Llama), have gained significant attention in recent years due to their small size (15 kDa), high affinity, and robust stability. Our experienced team at Biorbyt is dedicated to delivering high-quality nanobodies customized to your unique requirements.
Service Highlights
Efficient Single B Platform
Utilizing our proprietary single B platform, we efficiently isolate and culture B cells from immunized Camelids, which enables rapid generation of high-quality nanobodies tailored to your specific targets.
Rapid VHH Library Generation
Within just 4 weeks, we can generate a comprehensive VHH library derived from the immunized Camelid B cells. This serves as a valuable resource for identifying candidates with exceptional binding affinity.
Accelerated Screening Process
Our optimized screening process allows for the identification of VHH hits within 2 months, significantly reducing the timeline compared to traditional hybridoma methods.
Optimization with Mammalian Display
Our nanobodies can be further optimized using our mammalian cell display-based antibody engineering system to enhance specific properties such as stability or affinity.
Development Phases
Our streamlined workflow ensures rapid delivery from immunization to validated VHH hits:
Stage | Service Details | Est. Turnaround |
|---|---|---|
1. Camelid Immunization | Immunization of Alpacas or Llamas to elicit a strong immune response against the target antigen. | Standard (6-8 Weeks) |
2. Single B Isolation | Isolation of specific B cells using our proprietary Single B platform. | 1-2 Weeks |
3. VHH Library Generation | Construction of a comprehensive VHH library derived from the immunized B cells. | 4 Weeks |
4. Screening & Identification | High-throughput screening to identify VHH hits with high specificity. | Within 2 Months |
5. Optimization (Optional) | Engineering via mammalian cell display for enhanced affinity/stability. | Upon Request |