20-hydroxy Leukotriene B4

SKU: orb1984916

Description

20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist.

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Key Properties

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CAS Number	79516-82-8
MW	352.471
Formula	C₂₀H₃₂O₅
SMILES	OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Target	Endogenous Metabolite,Others

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

Endogenous Metabolite,Others

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