Amitriptyline hydrochloride

SKU: orb1310394

Description

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	549-18-8
MW	313.86
Purity	97.00%
Formula	C₂₀H₂₄ClN
SMILES	Cl.CN(C)CC\C=C1\c2ccccc2CCc2ccccc12
Target	Norepinephrine,Serotonin Transporter,Sigma receptor,Adrenergic Receptor,Histamine Receptor,Sodium Channel,5-HT Receptor,AChR,Trk receptor
Solubility	Ethanol:59 mg/mL (187.98 mM);DMSO:250 mg/mL (796.53 mM);H2O:12 mg/mL (38.23 mM)

Bioactivity

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Target IC50	5 hT receptor:3.45 nM\|5 hT2B receptor:40 nM\|DAT:2.58 μM (Ki)\|σ1 receptor:287 nM\|H4 receptor:33.6 nM\|H3 receptor:1 μM\|Norepinephrine receptor:13.3 nM\|5 hT2C receptor:6 nM\|5 hT4:7.31 nM\|mAChR:7.2 nM\|5 hT2:235 nM\|H1 Receptor:1.1 nM\|5 hT1A receptor:450 nM\|Adrenoceptor:24 nM\|5 hT1B receptor:40 nM\|5 hT2A receptor:4 nM Read more...
In Vivo	Amitriptyline (15 mg/kg, i.p.) activates TrkA and TrkB receptors and significantly reduces kainic acid-triggered neuronal cell death in mice. Amitriptyline (15 mg/kg and 30 mg/kg, i.p.) dose-dependently decrease the immobility time in the forced swimming test (FST) of mice. Amitriptyline (15 mg/kg, i.p.) shows a significant 24 h rhythm in the immobility time in the forced swimming test (FST) of mice. [7] Amitriptyline (1 mg/kg and 3 mg/kg) significantly increase the total distance travelled of mice in novel cages. Amitriptyline (10 mg/kg p.o., twice daily) considerably attenuate the hypothermic response to 8-OHDPAT and mCPP in mice. Amitriptyline (10 mg/kg p.o., twice daily) significantly reduces serotonin transporter density by approximately 20% in cortex of mice. [8] Read more...
In Vitro	Amitriptyline inhibits Forskolin-stimulated cyclic AMP accumulation with EC50 Values of 16.2 μM in intact CHO/DOR cells. Amitriptyline causes a concentration dependent stimulation of ERK1/2 and GSK-3β phosphorylation with EC50 Values of 9.0 μM in CHO/DOR cells. Amitriptyline (15 μM) causes a stimulation of ERK1/2 phosphorylation in C6 cells. Amitriptyline (30 μM) inhibits Forskolin-stimulated adenylyl cyclase activity and antagonizes ( )-U50,488 inhibitory effect in rat nucleus accumbens. Amitriptyline bind the extracellular domain of both TrkA and TrkB and promotes TrkA-TrkB receptor heterodimerization. Amitriptyline < 500 nM) promotes TrkA autophosphorylation in Primary neurons and induces neurite outgrowth in PC12 cells. Amitriptyline selectively protects T17 cells from apoptosis with EC50 of 50 nM. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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σ1, Tryptizol, Tropomyosin related kinase receptor, Trk Receptor, Trk receptor, TrkA/TrkB, Trkreceptor, Sodium Channel, SodiumChannel, SLC6A4, psychiatric, SerotoninTransporter, Serotonin Transporter, Serotonin Receptor, SERT, Sigmareceptor, Sigma receptor, heterodimerization, HistamineReceptor, Histamine Receptor, Muscarinic acetylcholine receptor, Norepinephrine receptor, inhibit, Inhibitor, mAChR, pain, Na+ channels, Na channels, neurotrophins, neuropathic, neurologic, 5-HT, 5-HT4, 5-HTT, 5HTReceptor, 5-hydroxytryptamine Receptor, Adrenergic Receptor, AdrenergicReceptor, 5-HT2, 5-HT Receptor, 5HT Receptor, Amitriptyline HCl, Amitriptyline Hydrochloride, Amitriptyline hydrochloride, Amitriptyline, Annoyltin, depression, Domical, diseases, Beta Receptor

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Compound Identifiers

PubChem CID

11065 ↗

Key Properties

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No computed properties available.

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