AZ7550 hydrochloride

SKU: orb1308863

Description

AZ7550 hydrochloride is the active metabolite of AZD9291 (Osimertinib) and acts as an IGF1R inhibitor with an IC50 of 1.6 µM. This small molecule is a valuable research tool for studying IGF-1R signaling in cancer models, applicable in both in vitro biochemical assays and in vivo preclinical research.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2309762-40-9
MW	522.04
Purity	99.65%
Formula	C₂₇H₃₂ClN₇O₂
SMILES	C=CC(NC1=CC(NC2=NC=CC(C3=CN(C4=C3C=CC=C4)C)=N2)=C(C=C1N(CCNC)C)OC)=O.[H]Cl
Target	EGFR,IGF-1R,Drug Metabolite
Solubility	DMSO:1.5 mg/mL (2.87 mM)

Bioactivity

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Target IC50	IRR:840 nM \|TEC:1317 nM \|MLK1:88 nM \|ERB4:195 nM \|FLT4:1784 nM \|IGF-1R:1.6 μM \|FES:449 nM \|FAK:995 nM \|FLT3:302 nM \|BLK:977 nM \|Insulin receptor:1256 nM \|Ack1:156 nM \|MNK2:228 nM \|Brk:843 nM \|PYK2:2288 nM \|ALK:420 nM Read more...
In Vitro	AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM). Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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PYK2, Txk, TEC, Ins R, Inhibitor, HER1, FLT4, IGF-1R, IGF1R, FLT3, FES, FAK, ErbB4, ErbB-1, EGFR, Epidermal growth factor receptor, IRR, inhibit, MNK2, MLK1, AZ7550, AZ-7550, AZ7550 hydrochloride, AZ7550 Hydrochloride, AZ-7550 Hydrochloride, AZ-7550 hydrochloride, AZ7550 hydrochloride (1421373-99-0 free base), AZ 7550, AZ 7550 Hydrochloride, BLK, BTK, 1421373-99-0, 1421373-99-0 free base, ACK1, ALK, BRK, Drug Metabolite

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Compound Identifiers

PubChem CID

132274051 ↗

Key Properties

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No computed properties available.

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