AZ7550 trimesylate salt

SKU: orb1708048

Description

AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib and functions as an IGF1R inhibitor. It is utilized in research applications for non-small cell lung cancer, including in vitro cell-based assays and in vivo xenograft model studies.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2319837-99-3
MW	773.9
Purity	99.24%
Formula	C₃₀H₄₃N₇O₁₁S₃
SMILES	O=C(NC1=CC(NC2=NC(C3=CN(C)C4=C3C=CC=C4)=CC=N2)=C(C=C1N(CCNC)C)OC)C=C.O=S(O)(C)=O.O=S(O)(C)=O.O=S(O)(C)=O
Target	IGF-1R,EGFR,Drug Metabolite
Solubility	DMSO:20 mg/mL (25.84 mM)

Bioactivity

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Target IC50

In Vitro

AZ7550 trimesylate salt (Compound 28) demonstrates a potency and selectivity profile broadly similar to the parent compound AZD9291. Inhibiting the double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild-type (WT) cell line LoVo, AZ7550 trimesylate salt exhibits IC50s of 45, 26, and 786 nM, respectively. Moreover, it inhibits the antiproliferative cell lines H1975 (DM), PC9 (AM), and Calu3 (WT) with GI50s of 19, 15, and 537 nM, respectively.

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MNK2, MLK1, IRR, FES, ErbB4, FAK, FLT4, FLT3, Ins R, IGF-1R, IGF1R, 1421373-99-0, 1421373-99-0 free base, ALK, ACK1, AZ 7550, AZ 7550 Mesylate, AZ 7550 Trimesylate, AZ-7550, AZ7550, AZ7550 Mesylate, AZ-7550 Mesylate, AZ7550 Mesylate (1421373 99 0 free base), AZ7550 Mesylate (1421373990 free base), AZ-7550 Mesylate (1421373-99-0 free base), AZ7550 Trimesylate, AZ-7550 Trimesylate, AZ7550 trimesylate salt (1421373-99-0 free base), BLK, BTK, BRK, PYK2, TEC, Txk

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Compound Identifiers

PubChem CID

134611624 ↗

Key Properties

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No computed properties available.

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