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DM1-PEG4-DBCO

SKU: orb1988453

Description

DM1-(PEG)4-DBCO is a drug-linker conjugate that combines the potent microtubulin inhibitor mertansine (DM1) with the DBCO-PEG4-Ahx linker for developing antibody-drug conjugates (ADCs). This conjugation aims to mitigate systemic toxicity associated with maytansine while improving tumor-specific delivery, leveraging DM1's ability as an antibody-conjugatable maytansinoid.

Images & Validation

Key Properties

MW1198.79
FormulaC63H80ClN5O16
SMILESCOC1=CC(C/C(C)=C/C=C/[C@@H](OC)[C@]2(O)NC(OC([C@@H](C)C(O3)[C@]3(C)[C@@H](OC([C@H](C)N(C)C(CCCOCCOCCOCCOCCNC(CCC(N4CC(C=CC=C5)=C5C#CC6=C4C=CC=C6)=O)=O)=O)=O)CC7=O)C2)=O)=CC(N7C)=C1Cl
TargetDrug-Linker Conjugates for ADC

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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DM1-PEG4-DBCO (orb1988453)

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