Dopamine D4 receptor ligand 3

SKU: orb3027813

Description

Dopamine D4 receptor ligand 3 (Compound 16) functions as a dopamine D4 receptor (D4R) antagonist with a pKi of 8.86. In HEK-293T cells, it shows pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors, respectively. This compound inhibits the activity of human glioma cell lines U87 MG, T98G, and U251 MG, and it induces ROS production and mitochondrial dysfunction in these glioma cells.

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Key Properties

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CAS Number	3082344-46-2
MW	489.56
Formula	C₂₈H₃₁N₃O₅
SMILES	O=C(O)C(=O)O.O=C1N(C=2C=CC=CC2CC1)CCCN3CCN(C=4C=CC=5C=CC=CC5C4)CC3
Target	Reactive Oxygen Species,Dopamine Receptor

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

Reactive Oxygen Species,Dopamine Receptor

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