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DQP-997-74

SKU: orb1942238

Description

Dihydroquinoline-pyrazoline DQP-997-74 (compound 2i) is a selective N-methyl-d-aspartate receptor (NMDAR) inhibitor that preferentially targets GluN2C/D subunits, with IC50 values of 0.069 μM and 0.035 μM, respectively, and possesses blood-brain barrier permeability. It enhances its inhibitory potency in a time-dependent manner when combined with the agonist glutamate, reducing epileptogenic events in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 is potentially applicable for the study of NMDAR-related neurological diseases.

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Key Properties

CAS Number2377187-09-0
MW570.37
FormulaC28H19Cl2F2N3O4
SMILESO=C(O)CC(F)(F)C(=O)N1N=C(C=2C(=O)NC=3C=CC=CC3C2C=4C=CC(Cl)=CC4)CC1C5=CC=C(Cl)C=C5
TargetOthers

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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DQP-997-74 (orb1942238)

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