HDGFRP2/PSIP1-IN-1

SKU: orb2665004

Description

Compound BPP (HDGFRP2/PSIP1-IN-1) is a dual inhibitor targeting the PWWP domains of Hepatoma-derived Growth Factor Related Protein 2 (HDGFRP2) and its homologue PSIP1. This compound effectively hinders the occurrence and progression of Diffuse Intrinsic Pontine Glioma (DIPG). It demonstrates binding affinity with a Kd value of 7 μM for HDGFRP2, indicative of its efficient ligand efficacy at 0.47. Additionally, Compound BPP exhibits a Kd value of 27 μM when binding to the PSIP1 PWWP domain, and a Kd value of 14 μM against HDGFRP3, confirming its potency as an inhibitor within the HDGFRP2 PWWP subfamily.

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Key Properties

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CAS Number	166196-54-9
MW	224.06
Formula	C₈H₆BrN₃
SMILES	BrC1=CNN=C1C=2C=CN=CC2
Target	Others

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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