α-Helical CRF (9-41) TFA

SKU: orb1980134

Description

α-Helical CRF (9-41) is a synthetic peptide antagonist that targets corticotropin-releasing factor (CRF), effectively inhibiting CRF-induced adrenocorticotropic hormone (ACTH) release both in vitro, with isolated rat anterior pituitary cells at concentrations of 0.5 to 5 µM, and in vivo, in non-anesthetized, intact rats at doses ranging from 0.02 to 0.6 µmol/kg. Moreover, it prevents stress-induced ACTH release at a dose of 0.6 µmol/kg in rats and demonstrates the ability to enhance social interaction times in a rat model addressing nicotine-induced conditioned anxiety, in addition to decreasing binge-like ethanol consumption in mice.

Images & Validation

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Key Properties

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MW	3826.36
Formula	C₁₆₆H₂₇₄N₄₆O₅₃S₂.XCF₃COOH
SMILES	OC(CC[C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC=N1)NC([C@@H](NC([C@]([H])([C@@H](C)O)NC([C@@H](NC([C@H](CC(O)=O)N[H])=O)CC(C)C)=O)=O)CC2=CC=CC=C2)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N)=O)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)C)=O)C)=O)=O)=O)C)=O)=O)=O)=O)C)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)=O.OC(C(F)(F)F)=O

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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