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IMR-1A

SKU: orb1304088

Description

IMR-1A

Research Area

Metabolism Research, Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number331862-41-0
MW325.36
Purity99.76%
FormulaC13H11NO5S2
SMILESCOc1cc(\C=C2\SC(=S)NC2=O)ccc1OCC(O)=O
TargetGamma-secretase,Drug Metabolite
SolubilityDMSO:4.23 mg/mL (13 mM)

Bioactivity

Target IC50
IMR-1:6 μMol/L.
In Vivo
The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish.
In Vitro
IMR-1 prevent the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth. A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared wit the control (DMSO).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

DrugMetabolite, Drug Metabolite, Inhibitor, Notch, IMR 1A, IMR1A, IMR-1A, inhibit, Gammasecretase

Similar Products

  • IMR-1A [orb1223148]

    >98% (HPLC)

    331862-41-0

    325.4

    C13H11NO5S2

    1 g, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg
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Key Properties

No computed properties available.

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IMR-1A (orb1304088)

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% DMSO +
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Available Sizes

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1 mg
$ 90.00
5 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 150.00
10 mg
$ 210.00
25 mg
$ 390.00
50 mg
$ 570.00
100 mg
$ 840.00
200 mg
$ 1,130.00
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