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IR-Crizotinib

SKU: orb1942717

Description

IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial glioblastoma (GBM) localization in mice. It has the ability to cross the blood-brain barrier and fluorescently mark GBM, and demonstrates efficacy in inhibiting glioma proliferation and invasion both in vitro and in vivo, making it significant in cancer research.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number2387927-74-2
MW1024.88
FormulaC53H57Cl2FIN7O
SMILESC(\C=C\1/C(C)(C)C=2C(N1C)=CC=CC2)=C\3C(=C(/C=C/C=4C(C)(C)C=5C([N+]4C)=CC=CC5)CCC3)N6CCC(CC6)N7C=C(C=N7)C=8C=C(O[C@H](C)C9=C(Cl)C(F)=CC=C9Cl)C(N)=NC8.[I-]
TargetNF-κB

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

IR-Crizotinib (orb1942717)

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