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IR-Crizotinib

SKU: orb1942717

Description

IR-Crizotinib is a fluorescent conjugate of the NIK inhibitor Crizotinib and the NIR dye IR-786. It crosses the blood-brain barrier to localize and mark intracranial glioblastoma in mice, demonstrating utility for in vivo imaging and in vitro studies of glioma proliferation and invasion.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number2387927-74-2
MW1024.88
FormulaC53H57Cl2FIN7O
SMILESC(\C=C\1/C(C)(C)C=2C(N1C)=CC=CC2)=C\3C(=C(/C=C/C=4C(C)(C)C=5C([N+]4C)=CC=CC5)CCC3)N6CCC(CC6)N7C=C(C=N7)C=8C=C(O[C@H](C)C9=C(Cl)C(F)=CC=C9Cl)C(N)=NC8.[I-]
TargetNF-κB

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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IR-Crizotinib (orb1942717)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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