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JQ dS-4

SKU: orb2695173

Description

JQ dS-4 is a PROTAC degrader of BRG1/BRM/SMARCA4, achieving complete degradation in glioma models with DC50 values from 9-390 nM. It reduces viability in H3K27M glioma, prostate, thyroid, and salivary gland cancer cell lines, supporting its investigation in oncology research for both in vitro and in vivo applications.

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number2688882-69-9
MW719.15
FormulaC37H31ClN8O6
SMILESO=C(NC=1C=CN=C(Cl)C1)NC=2C=CN=C(C#CC3=CC=CC(=C3)C(=O)NCCCCNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6)C2
TargetEpigenetic Reader Domain

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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JQ dS-4 (orb2695173)

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