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KDX1381

SKU: orb3135029

Description

KDX1381 is a bivalent CK2α inhibitor with an IC50 of 17 nM and a KD of 54 nM. It demonstrates antitumor activity in murine 786-O and A375 xenograft models. Furthermore, when combined with a vascular endothelial growth factor receptor (VEGFR) inhibitor or DNA-damaging agents, KDX1381 enhances antitumor effects in mouse hepatocellular carcinoma and glioma models.

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Key Properties

CAS Number2757728-47-3
MW634.70
FormulaC32H32F2N6O4S
SMILESO=C(C=1NC=2C=CC(F)=CC2C1C=3N=NN(C3)CC4CCN(CCNS(=O)(=O)C=5C=CC(=CC5)C=6C(F)=CC=CC6O)CC4)C
TargetCasein Kinase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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KDX1381 (orb3135029)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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