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Mutant IDH1-IN-1

SKU: orb1306660

Description

Mutant IDH1-IN-1 is a highly potent small molecule inhibitor targeting the R132H mutant IDH1 enzyme, demonstrating an IC50 value below 0.1 µM. It is a valuable research tool for investigating mutant IDH1-driven mechanisms in cancers such as glioma and AML, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1355326-21-4
MW498.59
Purity99.49%
FormulaC30H31FN4O2
SMILESCc1ccccc1C(N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCCC1
TargetDehydrogenase,Isocitrate Dehydrogenase (IDH)
SolubilityDMSO:60 mg/mL (120.34 mM)

Bioactivity

Target IC50
IDH1 (R132H):< 0.1 μM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Isocitrate Dehydrogenase, IsocitrateDehydrogenase(IDH), Isocitrate Dehydrogenase (IDH), IsocitrateDehydrogenase, Mutant IDH1 IN 1, mutant IDH1 R132H, Mutant IDH1IN1, Mutant IDH-1-IN-1, Mutant IDH1-IN-1, IDH, IDH1-IN-1

Similar Products

  • IDH1-IN-1 [orb1226462]

    >98%(HPLC)

    1355326-21-4

    498.6

    C30H31FN4O2

    10 mg, 2 mg, 5 mg, 25 mg, 1 g, 500 mg, 200 mg, 50 mg, 100 mg
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Key Properties

No computed properties available.

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Mutant IDH1-IN-1 (orb1306660)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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2 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 110.00
5 mg
$ 110.00
10 mg
$ 140.00
25 mg
$ 240.00
50 mg
$ 320.00
100 mg
$ 450.00
200 mg
$ 590.00
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