NAMPT inhibitor-linker 1

SKU: orb1987909

Description

NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively.

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Key Properties

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CAS Number	2241019-57-6
MW	668.71
Formula	C₃₆H₃₇FN₆O₆
SMILES	Fc1cc(NC(=O)[C@H]2C[C@@H]2c2cccnc2)ccc1CNC(=O)c1ccc(cc1)N1CCN(CC1)C(=O)CCOCCN1C(=O)C=CC1=O
Target	Drug-Linker Conjugates for ADC

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Drug-Linker Conjugates for ADC

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