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NCI 126224

SKU: orb1979970

Description

NCI 126224 is a selective TLR4 antagonist that potently inhibits LPS-induced nitric oxide (IC50 = 0.31 µM), NF-κB activity, and pro-inflammatory cytokine production in macrophages and microglial cells. It also shows activity against TLR2/6-mediated NO production, making it a useful research tool for studying innate immunity and inflammation in vitro.

Research Area

Immunology & Inflammation

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Key Properties

CAS Number65974-52-9
MW265.20
FormulaC12H11NO6
SMILESCOC(/C(C(OC)=O)=C/C1=C(C=CC=C1)[N+]([O-])=O)=O
TargetTLR

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Key Properties

No computed properties available.

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NCI 126224 (orb1979970)

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