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NEO214

SKU: orb2565692

Description

NEO214, an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol, exhibits anti-cancer activity and blood-brain barrier (BBB) permeability. It prevents autophagy-lysosome fusion, blocking autophagic flux and triggering glioma cell death via mTOR activation and TFEB (Transcription Factor EB) aggregation. NEO214 inhibition of Macroautophagy/autophagy in glioblastoma cells may overcome chemotherapy resistance in glioblastoma.

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Key Properties

CAS Number1361198-80-2
MW453.57
FormulaC27H35NO5
SMILESC(OCC=1CC[C@H](C(C)=C)CC1)(=O)N2CC(CC2=O)C3=CC(OC4CCCC4)=C(OC)C=C3
TargetAutophagy,mTOR

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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NEO214 (orb2565692)

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