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Olutasidenib

SKU: orb1307932

Description

Olutasidenib

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1887014-12-1
MW354.79
Purity99.59%
FormulaC18H15ClN4O2
SMILESC[C@H](Nc1ccc(C#N)n(C)c1=O)c1cc2cc(Cl)ccc2[nH]c1=O
TargetIsocitrate Dehydrogenase (IDH),Dehydrogenase
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.27 mM);DMSO:122 mg/mL (343.87 mM)

Bioactivity

Target IC50
IDH1 (R132C):114 nM (IC50)|IDH1 (R132H):21.2 nM (IC50)
In Vivo
In HCT116-IDH1-R132H/+ xenograft bearing female BALB/c Nude mice, Olutasidenib (three oral doses (12.5, 25, and 50 mg/kg) in 12-hour intervals) shows effective anti-tumor activity .
In Vitro
Olutasidenib is highly selective for IDH1 isoforms, showing no appreciable inhibition against wild-type IDH1 (> 20 μM) and IDH2 mutants (R172K and R140Q: both > 20 μM). Olutasidenib effectively suppresses 2-HG production by multiple IDH1-R132 mutants (R132H, R132C, R132G, R132L), displaying Olutasidenib (FT-2102) could be efficacious against most IDH1-R132 mutant-expressing tumors .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Olutasidenib, mutant, Isocitrate Dehydrogenase (IDH), Isocitrate Dehydrogenase, IsocitrateDehydrogenase, IsocitrateDehydrogenase(IDH), inhibit, FT 2102, FT2102, FT-2102, IDH, IDH1- R132C, IDH1- R132H, Inhibitor, 2-HG, R132C-IDH1, R132H-IDH1

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Key Properties

No computed properties available.

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Olutasidenib (orb1307932)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 220.00
1 ml x 10 mM (in DMSO)
$ 230.00
10 mg
$ 320.00
25 mg
$ 560.00
50 mg
$ 790.00
100 mg
$ 1,090.00
200 mg
$ 1,430.00
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