PAMP-12 (unmodified)

SKU: orb2278927

Description

PAMP-12 (unmodified), an endogenous peptide and potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM), induces hypotension by inhibiting catecholamine release from sympathetic nerve endings and adrenal chromaffin cells.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	929905-12-4
MW	1619.91
Formula	C₇₇H₁₁₈N₂₄O₁₅
SMILES	C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)N)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC=2C=3C(NC2)=CC=CC3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CO)=O)CC(C)C)=O)C)=O)=O)CCCCN)=O)CC(N)=O)=O)C=4C=5C(NC4)=CC=CC5
Target	MRGPR

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

MRGPR

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