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PKM2-IN-8

SKU: orb2945714

Description

PKM2-IN-8 (Compound 9b) is an inhibitor of pyruvate kinase M2 (PKM2) with an IC50 of 0.31 μM. It exhibits potent antiproliferative activity against U87MG glioma cells. PKM2-IN-8 induces early apoptosis and reduces lactate levels. This compound is useful for research in glioblastoma.

Research Area

Cell Biology, Metabolism Research

Images & Validation

Key Properties

MW355.353
FormulaC19H13N7O
SMILESC1=CC=C2C=C(C=CC2=C1)C3=NN(N=N3)CC(=O)C4=CN=C5N4C=CC=N5
TargetApoptosis,PKM

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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PKM2-IN-8 (orb2945714)

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