Pomalidomide-PEG1-C2-N3

SKU: orb1988392

Description

Pomalidomide-PEG1-C2-N3, a conjugate of an E3 ligase ligand-linker, incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, commonly used in PROTAC technology. This compound enables the design of the selective CDK6 PROTAC degrader CP-10, which effectively induces CDK6 degradation with a DC50 value of 2.1 nM.

Research Area

Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	2271036-44-1
MW	386.36
Formula	C₁₇H₁₈N₆O₅
SMILES	[N-]=[N+]=NCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
Target	E3 Ligase Ligand-Linker Conjugate,Others

Storage & Handling

−

Storage	-20°C
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol

E3 Ligase Ligand-Linker Conjugate,Others

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols