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Sp-8-Br-PET-cGMPS

SKU: orb2646237

Description

Sp-8-Br-PET-cGMPS is a membrane-permeable PKG activator and an inhibitor of the membrane-permeable retinal cGMP-gated ion channels (cGMP-gated ion channel). It also serves as an activator for cGMP-dependent protein kinase I α and β. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, Sp-8-Br-PET-cGMPS does not undergo metabolic side effects and exhibits stronger lipophilicity and permeability compared to Sp-8-pCPT-cGMPS. This compound is useful for investigating the role of the cGMP signaling pathway in the nervous system.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number172806-21-2
MW540.28
FormulaC18H15BrN5O6PS
SMILESBrC=1N(C2=C(N1)C(=O)N3C(N2)=NC(=C3)C4=CC=CC=C4)[C@H]5[C@H](O)[C@]6([C@](O5)(COP(=O)(S)O6)[H])[H]
TargetPKA

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

Sp-8-Br-PET-cGMPS (orb2646237)

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