TM2 TEAD inhibitor

SKU: orb1979922

Description

TM2 TEAD inhibitor is an effective and reversible inhibitor of TEA domain transcription factors, exhibiting IC₅₀ values of 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively. TM2 TEAD inhibitor blocks TEAD-YAP binding and suppresses its transcriptional activity, exhibiting significant antiproliferative effects in YAP-dependent cancer cells. It demonstrates potent efficacy both as a monotherapy and in combination with MEK inhibitors. Furthermore, TM2 TEAD inhibitor strongly inhibits YAP-dependent liver organoid growth in vitro, supporting its potential application as an anticancer therapeutic strategy.

Research Area

Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1008768-41-9
MW	435.57
Purity	99.91%
Formula	C₂₆H₃₃N₃O₃
SMILES	O=C(NC=1C=CC=CC1)N2CCN(C(=O)C=3C=CC=C(OCCC4CCCCC4)C3)CC2
Target	Others,YAP

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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TEAD-IN-8

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Gene Symbol

Others,YAP

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