Zotiraciclib citrate

SKU: orb2815085

Description

Zotiraciclib (also known as TG02 and SB1317) is an innovative small-molecule compound with potent inhibitory effects on CDK, JAK2, and FLT3. By inhibiting cyclin-dependent kinase 9 (CDK9) and depleting Myc, it serves as a treatment for cancers that can penetrate the blood-brain barrier. Zotiraciclib is one of the numerous CDK inhibitors under investigation; other compounds targeting CDK9, utilized for treating acute myeloid leukemia, include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, with 80% of glioblastomas exhibiting this characteristic.

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Key Properties

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CAS Number	1204918-73-9
MW	564.59
Formula	C₂₉H₃₂N₄O₈
SMILES	OC(=O)CC(O)(CC(O)=O)C(O)=O.CN1C\C=C\CCOC2=CC(=CC=C2)C3=CC=NC(NC4=CC=CC(C1)=C4)=N3

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

87368269 ↗

Key Properties

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No computed properties available.

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