1,4-Anthraquinone

SKU: orb1217784

Description

1,4-Anthraquinone is an anticancer drug that blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of L1210 leukemic cells in the same nanomolar range as daunorubicin in vitro.1,4-Anthraquinone is proposed as a novel pre-column reagent for high performance liquid chromatography (HPLC) determination of N-acetylcysteine (NAC) and captopril (CAP) in pharmaceutical formulations.

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Key Properties

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CAS Number	635-12-1
MW	208.2
Purity	>98% (HPLC)
Formula	C₁₄H₈O₂
SMILES	O=C(C=C1)c2cc3ccccc3cc2C1=O
Target	Others

Bioactivity

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In Vitro

1, 4-Anthraquinone (2.62 nM-1.6 μM; 4 days) induces significant antiproliferative and cytotoxic effects in L1210 cells after 4 days at 6.55 nM; inhibits cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4.1, 4-Anthraquinone (40.96 nM-25 μM; 30 min; L1210 cells) inhibits nucleoside transport by 71 and 92% and DNA synthesis by 84 and 96% at 4 and 10 μM, respectively, and are both irreversible upon drug removal.1, 4-Anthraquinone (0.1024-25 μM; 3 h) inhibits the rates of RNA and protein syntheses (IC50 = 2 μM) in a dose-dependent manner. Cell Proliferation Assay Cell line: L1210 cells. Concentration: 2.62 nM-1.6 μM Incubation time: 4 days. Result: Induced significant antiproliferative and cytotoxic effects after 4 days at 6.55 nM. Cell Viability Assay Cell line: L1210 cells. Concentration: 2.62 nM-1.6 μM Incubation time: 4 days. Result: Inhibited cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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