14-Deoxy-11,12-didehydroandrographolide

SKU: orb1296147

Description

14-Deoxy-11,12-didehydroandrographolide (AP10) is a bioactive diterpenoid known for its ability to suppress NF-κB activation. This mechanism underpins its research applications in studying hypertension, inflammation, asthma, and cancer, with utility in both cellular and animal model experiments.

Research Area

Signal Transduction

Images & Validation

−

Key Properties

−

CAS Number	42895-58-9
MW	332.43
Purity	99.93% (May vary between batches)
Formula	C₂₀H₂₈O₄
SMILES	CC1(CO)C(O)CCC2(C)C(CCC3=CCOC3=O)C(=C)CCC12
Target	NF-κB
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.02 mM);DMF:100 mg/mL (300.82 mM)

Bioactivity

−

In Vivo	14-deoxy-11,12-didehydroandrographolide (1 mg/kg) significantly decreases resistance and restores Cdyn in Ovalbumin-challenged mice in response to methacholine. Read more...
Cell Research	A549 cells (3×10^3/well), BEAS-2B cells (5×10^3/well), and RBL-2H3 cells (3×10^3/well) are seeded in flat-bottomed 96-well plates overnight and then incubated with increasing concentrations (3-120 μM) of 14-deoxy-11,12-didehydroandrographolide for 24 and 48 h at 37°C. Cell viability is analyzed using the CellTiter 96 AQueous cell proliferation assay. Absorbance is recorded at 490 nm. Read more...
Animal Research	Female BALB/c mice, 6 to 8 weeks old, are sensitized and challenged with OVA. Briefly, mice are sensitized by ip injections of 20 μg of OVA and 4 mg of Al(OH)3 suspended in 0.1 mL of saline on days 0 and 14. On days 22, 23, and 24, mice are challenged with 1% OVA aerosol for 30 min. 14-deoxy-11,12-didehydroandrographolide (0.1, 0.5, and 1 mg/kg) or vehicle (1% DMSO) in 0.1 mL of saline is given by i.p injections 2 h before and 10 h after each OVA aerosol challenge. Read more...

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

14-dehydro Andrographolide, 14Deoxy11,12didehydroandrographolide, 14-Deoxy-11,12-didehydroandrographolide, 14 Deoxy 11,12 didehydroandrographolide, AP10, AP-10, AP 10, Inhibitor, inhibit, Nuclear factor-kappaB, Nuclear factor-κB, NFκB, NF-κB, NF-kB, NFkB

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

343586 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols