1beta-Hydroxyalantolactone

SKU: orb1683977

Description

1β-Hydroxyalantolactone, isolated from Inula britannica flowers, modulates key inflammatory cytokines. It suppresses cellular expression while promoting secretion of TNF-α, IL-17, and IFN-γ, indicating a complex immunoregulatory role. This compound is used in rheumatoid arthritis research, with studies exploring its mechanisms in both cellular and animal models of inflammation.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	68776-47-6
MW	248.32
Purity	99.85%
Formula	C₁₅H₂₀O₃
SMILES	[H][C@@]12C[C@@]3(C)[C@H](O)CC[C@H](C)C3=C[C@]1([H])C(=C)C(=O)O2
Target	NF-κB,Interleukin,TNF,IL Receptor

Bioactivity

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In Vitro	Attenuating atopic dermatitis-like skin lesions induced by 2,4-dinitrochlorobenzene in the mouse, 1beta-Hydroxyalantolactone has been demonstrated.

Storage & Handling

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Storage	store at low temperature,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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IL Receptor, ILReceptor, IL-17 production, NF-κB, 1β-Hydroxyalantolactone, 1beta Hydroxyalantolactone, 1b-Hydroxyalantolactone, 1beta-Hydroxyalantolactone, 1betaHydroxyalantolactone, TNF-α

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Compound Identifiers

PubChem CID

71573444 ↗

Key Properties

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No computed properties available.

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