2,3-Dehydro-3,4-dihydro ivermectin

SKU: orb1984881

Description

This ivermectin analog exhibits potent antileishmanial activity against both promastigote and amastigote forms of L. amazonensis, with IC50 values of 13.8 µM and 3.6 µM, respectively. It demonstrates a favorable selectivity index due to low cytotoxicity in macrophages (IC50 = 65.5 µM), supporting its investigation for in vitro and in vivo models of leishmaniasis.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	1135339-49-9
MW	875.106
Formula	C₄₈H₇₄O₁₄
SMILES	CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C\C=C(C)\[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)\C=C\C=C3/CO[C@@H]4[C@H](O)C(C)C=C(C(=O)O1)[C@]34O)O2
Target	Others,Parasite

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

155859185 ↗

Key Properties

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No computed properties available.

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