24-Norursodeoxycholic acid

SKU: orb1310064

Description

Nor-UDCA, a side chain-shortened derivative of ursodeoxycholic acid (UDCA), exhibits enhanced anti-cholestatic, anti-inflammatory, and anti-fibrotic activities. It demonstrates superior efficacy to UDCA in murine models of sclerosing cholangitis, such as Mdr2 knockout mice, making it a valuable research tool for investigating cholestatic liver diseases.

Images & Validation

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Key Properties

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CAS Number	99697-24-2
MW	378.55
Purity	99.69%
Formula	C₂₃H₃₈O₄
SMILES	[H][C@@]12CC[C@H]([C@H](C)CC(O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@H](O)C[C@]2([H])C[C@H](O)CC[C@]12C
Target	Others
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.57 mM);DMSO:100 mg/mL (264.17 mM)

Bioactivity

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In Vitro

24-norUrsodeoxycholic acid markedly improved liver tests and liver histology and significantly reduced hydroxyproline content and the number of infiltrating neutrophils and proliferating hepatocytes and cholangiocytes. 24-norUrsodeoxycholic acid underwent extensive phase I/II metabolism (hydroxylation, sulfation, and glucuronidation), thereby increasing the hydrophilicity of biliary bile acid secretion. There was a coordinated induction of bile acid detoxifying enzymes (Cyp2b10, Cyp3a11, and Sult2a1) and efflux pumps (Mrp3 and Mrp4). Ursodeoxycholic acid, in contrast, increased alanine transaminase and alkaline phosphatase levels, had no significant effects on hydroxyproline content, and induced biliary transporters and detoxification enzymes to a much smaller extent than 24-norUrsodeoxycholic acid.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Norucholic acid, nor-UDCA, Inhibitor, 24 Norursodeoxycholic acid, 24Norursodeoxycholic acid, 24-Norursodeoxycholic acid

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Compound Identifiers

PubChem CID

192254 ↗

Key Properties

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No computed properties available.

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