Cart summary

You have no items in your shopping cart.

(2R/S)-6-PNG

SKU: orb2900986

Description

(2R/S)-6-PNG (6-Prenylnaringenin) is a potent and reversible Cav3.2 T-type Ca2+ channels (T-channels) blocker. (2R/S)-6-PNG can penetrate the blood-brain barrier (BBB). (2R/S)-6-PNG suppresses neuropathic and visceral pain in mice.

Images & Validation

−
(2R/S)-6-PNG

Key Properties

−
CAS Number68682-01-9
MW340.37
Purity>98% (HPLC)
FormulaC20H20O5
SMILESCC(C)=CCc1c(O)cc2OC(CC(=O)c2c1O)c1ccc(O)cc1
TargetHDAC
SolubilityIn Vitro: DMSO : 125 mg/mL (367.25 mM; Ultrasonic )

Bioactivity

−
In Vivo
(2R/S)-6-PNG (6-Prenylnaringenin; 10-30 mg/kg; i.p.; single dose; 15 min before Na2S) significantly reduced the Na2S-induced nociceptive behavior and/or referred hyperalgesia in onscious mice with intracolonic (i. col.) administration of Na2S, an H2S donor. (2R/S)-6-PNG (30 mg/kg; i.p.) prevents the increased number of phosphorylated ERK-positive cells following i. col. Na2S in laminae I-II, V-VI and X to which the primary afferent neurons project, and the Na2S-induced increase in the phosphorylated ERK-positive cell number. (2R/S)-6-PNG (0.01-1 and 0.1-10 nmol/paw; intraplantar administration) restores the mechanical allodynia induced by partial sciatic nerve ligation (PSNL) and by i.p. administration of Oxaliplatin (OHP) a, respectively, in a dose-dependent manner. (2R/S)-6-PNG (20-30 mg/kg; i.p.) significantly reverses the PSNL-induced allodynia. (2R/S)-6-PNG (10-20 mg/kg; i.p.) significantly reverses the OHP-induced allodynia (5 mg/kg; i.p.; single dose).
Read more...
In Vitro
(2R/S)-6-PNG (6-Prenylnaringenin) potently blocks Cav3.2, but exhibits minor effect on high-voltage-activated Ca2+ channels and voltage-gated Na+ channels in differentiated NG108-15 cells. On the basis of IC50 values, the proportion (Cav3.2/HVA) of the inhibition potency of (2R/S)-6-PNG on Cav3.2 and HVA-currents is 5.20, and that (Cav3.2/Nav) on Cav3.2 and Nav-currents is 3.54.
Read more...

Storage & Handling

−
StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

−
  • (2R/S)-6-PNG

    (2R/S)-6-PNG [orb1692894]

    98.00%

    68682-01-9

    340.37

    C20H20O5

    1 mg, 1 ml x 10 mM (in DMSO), 5 mg, 10 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol
HDAC

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Find More Protocols

(2R/S)-6-PNG (orb2900986)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Login to review

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 g
Enquire
100 mg
Enquire
500 mg
Enquire
2 mg
$ 210.00
Bulk Enquiry
Need technical support? Find your Distributor Return and Tax Policy

Email

info@biorbyt.com

UK Office

+44 (0)1223 859353

US Office

+1 (415) 906-5211

CN Office

+86 (27)-87663101

Distributors

biorbyt.com/distributor