3,5,6,7,8,3',4'-Heptemthoxyflavone

SKU: orb1297561

Description

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	1178-24-1
MW	432.42
Purity	99.93%
Formula	C₂₂H₂₄O₉
SMILES	COc1ccc(cc1OC)-c1oc2c(OC)c(OC)c(OC)c(OC)c2c(=O)c1OC
Target	PDE,Others
Solubility	DMSO:12 mg/mL (27.75 mM);10% DMSO+90% Corn Oil:1 mg/mL (2.31 mM)

Bioactivity

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In Vitro

3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF), extracted from C. unshiu peels using ethanol extraction and hexane fractionation, inhibited collagenase activity and increased type I procollagen content in UV-induced human dermal fibroblast neonatal (HDFn) cells. HMF also suppressed matrix metalloproteinases 1 (MMP-1) expression and induced type I procollagen protein expression in these cells. Additionally, HMF inhibited UVB-induced phosphorylation of MAPK cascade signaling components—ERK, JNK, and c-Jun—thereby reducing MMP-1 expression. Furthermore, HMF modulated the TGF-β/Smad signaling pathway by inducing Smad3 and suppressing Smad7 protein expressions in a dose-dependent manner in UV-induced HDFn cells.

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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3,5,6,7,8,3',4'-Heptemthoxyflavone, 3,3',4',5,6,7,8-heptamethoxyflavone, 3,5,6,7,8,3',4' Heptemthoxyflavone, 3,5,6,7,8,3',4'Heptemthoxyflavone, 3,?5,?6,?7,?8,?3',?4'-?Heptemthoxyflavone, gp120/CD4, IL Receptor, Inhibitor, inhibit, TNF-α

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Compound Identifiers

PubChem CID

150893 ↗

Key Properties

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No computed properties available.

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