7,3',4'-Tri-O-methylluteolin

SKU: orb1297487

Description

7,3',4'-Tri-O-methylluteolin is a trimethoxyflavone with documented anti-inflammatory, antibacterial, and antifungal properties. Research indicates it also exhibits moderate in vitro antitrypanosomal activity, demonstrating a MIC value of 19.0 µg/ml against Trypanosoma species.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience

Images & Validation

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Key Properties

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CAS Number	29080-58-8
MW	328.32
Purity	99.79%
Formula	C₁₈H₁₆O₆
SMILES	COc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(OC)c(OC)c1
Target	Interleukin,Parasite,Lipoxygenase,Antifungal,TNF,COX,Apoptosis
Solubility	DMSO:9 mg/mL (27.41 mM)

Bioactivity

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In Vitro

7,3',4'-Tri-O-methylluteolin significantly inhibited nitric oxide production and demonstrated slight reduction in prostaglandin-E2 level at tested concentrations. The production of pro-inflammatory cytokines, such as TNF-α±, IL-6, and IL-1β, were obviously reduced by 7,3',4'-Tri-O-methylluteolinin a concentration-dependent manner. Moreover, 7,3',4'-Tri-O-methylluteolinsignificantly induced reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level. In addition, we performed molecular docking and molecular dynamic simulations to study the interaction of 7,3',4'-Tri-O-methylluteolinwith inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase-2. Docking study showed its hydrogen bond interactions with key residues in the active site of inducible nitric oxide synthase and cyclooxygenase-2, enlightening its possible binding mode at the molecular level. The results of molecular dynamic simulations showed the stability of complexes and their interactions

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Cyclooxygenase, COX, 7,3',4' Tri O methylluteolin, 7,3',4'TriOmethylluteolin, 7,3',4'-Tri-O-methylluteolin, 5-Hydroxy-3',4',7-trimethoxyflavone, LOX, lipopolysaccharide, inhibit, Inflammation-related diseases, Inhibitor, Interleukin, Interleukin Related, IL Receptor, Tumor Necrosis Factor Receptor, TNFR, TNF, TNF Receptor, TNF-α, pro-inflammatory cytokines, RAW 264.7 macrophage

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Compound Identifiers

PubChem CID

5272653 ↗

Key Properties

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No computed properties available.

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