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9-Phenanthrol

SKU: orb1305887

Description

9-Phenanthrol is a selective inhibitor of the TRPM4 channel, a calcium-activated non-selective cation channel. This small molecule is utilized in both in vitro and in vivo research to investigate TRPM4's role in pathologies such as cardiac arrhythmias, stroke, and hypertension.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number484-17-3
MW194.23
Purity98.72% (May vary between batches)
FormulaC14H10O
SMILESOc1cc2ccccc2c2ccccc12
TargetTRP/TRPV Channel
SolubilityDMSO:19 mg/mL (97.82 mM);Ethanol:9 mg/mL (46.34 mM)

Bioactivity

In Vitro
In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50). Channel inhibition was voltage independent. The IC(50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

9 Phenanthrol, 9-Hydroxyphenanthrene, 9Phenanthrol, 9-Phenanthrol, ischemia-reperfusion injury, inhibit, NSC 50554, NSC50554, NSC-50554, Inhibitor, TRPVChannel, TRPV Channel, TRPM4, TRPChannel, TRP Channel, Transient receptor potential channels

Similar Products

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    >98% (HPLC)

    484-17-3

    194.2

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    100 mg, 1 g, 500 mg, 200 mg, 25 mg, 50 mg
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Key Properties

No computed properties available.

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9-Phenanthrol (orb1305887)

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1 ml x 10 mM (in DMSO)
$ 80.00
25 mg
$ 80.00
50 mg
$ 100.00
100 mg
$ 120.00
200 mg
$ 140.00
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