Acitretin

SKU: orb1308957

Description

Acitretin (Ro 10-1670) is a systemic retinoid employed as a research tool for studying psoriasis and other dermatological conditions. Its mechanisms of action, including modulation of keratinocyte differentiation and proliferation, are investigated in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Metabolism Research

Images & Validation

−

Key Properties

−

CAS Number	55079-83-9
MW	326.43
Purity	99.95%
Formula	C₂₁H₂₆O₃
SMILES	C(=C/C(=C/C=C/C(=C/C(O)=O)/C)/C)\C1=C(C)C(C)=C(OC)C=C1C
Target	Apoptosis,Autophagy,Retinoid Receptor
Solubility	DMSO:18.33 mg/mL (56.15 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+90% Corn Oil:1.5 mg/mL (4.6 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

−

In Vivo

Acitretin undergoes alpha-oxidation, chain shortening O-demethylation, and glucuronidation in the perfused rat liver. Acitretin rapidly appears in liver and muscle of rats, where it undergoes redistribution into skin and adipose tissue.

In Vitro

Acitretin stimulates ADAM10 promoter activity with an EC(50) of 1.5 mM and leads to an increase of mature ADAM10 protein that results in a two- to three-fold increase of the ratio between alpha- and beta-secretase activity in neuroblastoma cells. Acitretin (5-20 μM) impairs mitochondrial phosphorylation efficiency as demonstrated by the decrease in the state 3 respiration and ATP levels, and by the increase in the lag phase of ADP phosphorylation cycle, without affecting the membrane potential. Acitretin induces Ca(2+)-mediated mitochondrial permeability transition (MPT) and decreased the adenine nucleotide translocase (ANT) content. Acitretin preferentially inhibits the growth of SCL-1 cells in a dose- and time-dependent manner, but not of non-malignant keratinocyte HaCaT cells. Acitretin increases the levels of CD95 (Fas), CD95-ligand and Fas-associated death domain. Acitretin is able to induce apoptosis in skin cancer cells possibly via death receptor CD95 apoptosis pathway without affecting the viability of normal keratinocyte.

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Autophagy, Apoptosis, Acitretin, Etretin, Inhibitor, inhibit, Retinoid Receptor, Retinoic acid receptors, Retinoid X receptors, RetinoidReceptor, Ro 10-1670, RXR, RAR, RAR/RXR

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

5284513 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Acitretin (orb1308957)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

CAS Number:	925701-88-8
MW:	349.42
Formula:	C₂₁H₂₆NaO₃

CAS Number:	1185241-03-5
MW:	329.454
Formula:	C₂₁H₂₆O₃

Purity:	>98% (HPLC)
CAS Number:	55079-83-9
MW:	326.43
Formula:	C₂₁H₂₆O₃

Acitretin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Acitretin-CoA [orb3143936]

Acitretin sodium [orb1704709]

13-cis Acitretin D3 [orb1987549]

Acitretin [orb1224698]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Acitretin (orb1308957)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors