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AGI-14100

SKU: orb1702618

Description

AGI-14100 is an orally bioavailable small molecule inhibitor of mutant IDH1, developed for research into acute myeloid leukemia (AML). It has demonstrated activity in cellular assays and in vivo models, making it a tool for studying oncogenic metabolism and therapeutic strategies.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1448346-43-7
MW599.96
Purity99.91%
FormulaC29H22ClF4N5O3
SMILESN([C@H](C(NC1CC(F)(F)C1)=O)C2=C(Cl)C=CC=C2)(C(=O)[C@H]3N(C(=O)CC3)C4=CC(C#N)=CC=N4)C5=CC(F)=CC(F)=C5
TargetDehydrogenase,Isocitrate Dehydrogenase (IDH)
SolubilityDMSO:50 mg/mL (83.34 mM)

Bioactivity

Target IC50
HT1080 cells:1 nM|IDH1-R132H homodimer (mutation):6 nM
In Vivo
AGI-14100 (50 mg/kg; oral; single; female nude BALB/c mice) inhibition robust tumor 2-HG was achieved 12 hours post-dose demonstrating desirable in vivo results. AGI-14100 had decent oral pharmacokinetics (PK) properties in rats (F =44 %), dogs (F =18 %), and cynomolgus monkeys (F =43 %).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AGI14100, AGI-14100, AGI 14100, IDH1
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

AGI-14100 (orb1702618)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
$ 190.00
5 mg
$ 390.00
10 mg
$ 520.00
25 mg
$ 710.00
50 mg
$ 930.00
100 mg
$ 1,260.00
200 mg
$ 1,670.00
DispatchUsually dispatched within 3-5 working days
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