Alomfilimab Biosimilar (ICOS / CD278 Reference Antibody）

SKU: orb2703802

Description

Alomfilimab(KY-1044; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response.

Images & Validation

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Key Properties

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Antibody Type	Biosimilar Antibody
Clonality	Monoclonal
Target	Alomfilimab Biosimilar（Anti-ICOS / CD278 Reference Antibody）
Purity	>98%
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Alomfilimab Biosimilar（Anti-ICOS / CD278 Reference Antibody）

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